What is the 6-base genome?
The 6-base genome ads 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC) to the traditional nucleobases of adenine (A), cytosine (C), guanine (G), and thymine (T).
Integrate multiple modes of biology from a single sample in a single experiment to provide transformative insights into health and disease.
Current technologies are unable to reliably resolve both genetic and epigenetic sequences at low sample input and miss important information. biomodal’s duet multiomics solution evoC gives you access to the 6-base genome – all 4 canonical bases and distinguishes 5‑methylcytosine (5mC) and 5‑hydroxymethylcytosine (5hmC) – from a single 5ng DNA sample, in a single experiment, with high accuracy.
Combined epigenetic and genetic analysis in a single sequencing run lets you access the most critical information from your DNA samples.
Better characterise liquid biopsy and genomic DNA samples of early stage cancer for diagnostic and therapy development.
Combined data reveals the role of methylation in neurodegeneration.
Pinpoint epigenetic changes that determine patterns of disease and health throughout a lifespan.
Detect minute epigenetic changes to better understand maternal and foetal health.
Improved DNA-based diagnostics with the ability to see disease-relevant changes from low input samples
A true 6-base genome that distinguishes 5mC and 5hmC together with all four canonical bases to measure multiple modes of biology
Assess all four canonical bases plus modified cytosine
The 6-base genome ads 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC) to the traditional nucleobases of adenine (A), cytosine (C), guanine (G), and thymine (T).
We are delighted to present BaseSpace Sequence Hub data for duet multiomics solution +modC.
RNA sequencing (RNA-seq) has become immensely popular and indispensable in modern biological research. We look at the considerations and challenges of this technology.
We can help you reveal new data and multimodal insights from your research.