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bml POS 6base Multimodal data is a powerful lbx platform for cancer detection enabling discovery of epigenetic genetic fragmentomics biomarkers in a single workflow EACR2026 4JUN26 scaled
  • Poster

6-base multi-modal data is a powerful liquid biopsy platform for cancer detection, enabling the discovery of epigenetic, genetic and fragmentomics biomarkers in a single workflow

We evaluated 6-base sequencing with duet evoC, which simultaneously profiles 5mC, 5hmC, genetic variants and fragmentomics features from a single cfDNA sample.

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bml POS EACR2026 Single stranded ligation enhances the performance of the duet evoC 6 base assay enhancing value in low DNA input applications including liquid biopsy 4JUN26 scaled
  • Poster

Single stranded ligation enhances the performance of the duet evoC 6- base assay, enhancing value in low DNA input applications including liquid biopsy

The ssDNA duet workflow achieves ultra‑low limits of detection by combining high material recovery with outstanding sensitivity and specificity across genomic and epigenetic features.

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Adam Sowalski Poster 14APR26 scaled
  • Poster

Integrative Dual ctDNA 5mC/5hmC Methylomics and Clonal Reconstruction Infertumor Transcription and Resistance Phenotypes in Metastatic Prostate Cancer

Serial plasma dual 5mC/5hmC profiling moved liquid biopsy beyond mutation detection toward transcriptome-like tumor-state and resistance monitoring in mCRPC

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bml POS AACR2026 importance of high analytical sensitivity and specificity of 5 and 6 base assays to enhance detection of ctDNA in liquid biopsy scaled
  • Poster

The importance of high analytical sensitivity and specificity of 5 and 6-base assays to enhance the detection of ctDNA in liquid biopsy applications

We investigated the impact of a duet single stranded ligation workflow on methylation LoD (further details on duet single stranded ligation workflow are provided in poster #121) across duet +modC (which provides 5-base data) and duet evoC (which provides 6-base data, distinguishing between 5mC and 5mC).

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FAA scaled
  • Poster

Simultaneous identification of methylation and somatic variants can improve sensitivity for cancer detection and monitoring

We demonstrate the value of integrating genetic and epigenetic information from a single cfDNA assay using the duet evoC technology, which enables simultaneous extraction of complete genetics and complete epigenetics from the same sample.

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POS bml Using 6 base genome for full multiomic analysis of cfDNA through combined methyltion fragmentomic analysis to enhance classification of clinical cancer cfDNA samples AACR 2026 scaled
  • Poster

Using the 6-base genome for full multiomic analysis of cfDNA through combined methylation and fragmentomic analysis to enhance classification of clinical cancer cfDNA samples

Here, we assess the contribution of combined fragmentomic and epigenetic features to ctDNA detection in cfDNA from healthy individuals and colorectal cancer (CRC) patients.

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6-base genome reveals the reality of DNA methylation biomarkers of ageing
  • Poster

6-base genome reveals the reality of DNA methylation biomarkers of ageing

This study demonstrates the value of moving beyond legacy epigenetic sequencing technologies that provide a modC readout.

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Characterising cancer 6-base genomes using fresh frozen and formalin fixed tissue
  • Poster

Characterising cancer 6-base genomes using fresh frozen and formalin fixed tissue

This poster demonstrates compatibility of duet evoC with formalin-damaged DNA including clinical FFPE samples.

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Inferring gene regulation from 6-base sequencing data in multiple tissues
  • Poster

Inferring gene regulation from 6-base sequencing data in multiple tissues

Patterns of 5hmC and 5hmC provide insight into tissue-specific gene expression with the ability to better distinguish high and low expressed genes than 5mC or 5modC data.

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Mapping human tissues with 6-base sequencing 
  • Poster

Mapping human tissues with 6-base sequencing 

Using modality XPLR, we reveal variation in 5mC and 5hmC levels across tissues, with a pronounced increase in 5hmC in cerebellum and concomitant decrease in 5mC.

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Inferring gene regulation
  • Poster

Inferring gene regulation from 6-base sequencing data

Patterns of 5hmC and 5hmC provide a view on tissue-specific gene expression.

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Synergy-with-decitabine-expands-the-utility-of-talazoparib-a-novel-therapeutic-strategy-for-BRCA-proficient-pancreatic-cancer
  • Poster

Synergy with decitabine expands the utility of talazoparib: A novel therapeutic strategy for BRCA-proficient pancreatic cancer

The combination of PARPi (Talazoparib – TAL) and DNMTi (Decitabine – DAC) functions synergistically to inhibit PCa cell lines and patient-derived PTOs.

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