Resources
Resource types
- Poster
Circulating tumor DNA (ctDNA) purity can be used to predict therapy response of metastatic castration-resistant prostate cancer (mCRPC) to PD-L1/PARP1 inhibition.
- Poster
We present a computational toolkit to analyse 5mC and 5hmC modifications at scale and describe its performance on a novel liquid biopsy dataset.
- Poster
Professor Ellen Heitzer’s lab at the Medical University of Graz analysed eight samples from localised PCa, metastatic PCa, and suspicious Pca (men with elevated serum PSA and/or suspect digital rectal examination but negative biopsy) using the duet multiomics solution evoC.
- Poster
Learn how 6-base sequencing reveals 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC) have important roles in the regulation of genome dynamics. Deregulation of TET can spur an increase of 5hmC in heterochromatin which could potentially be an early biomarker of genome dysfunction that lead to diseases.
- Poster
To address the difficulties of analysing methylation data, this poster presents modality, an efficient and scalable analysis package for 5- and 6-base genomes.
- Poster
This poster demonstrates that the combination of 5mC and 5hmC is highly effective for early-stage CRC detection in cfDNA - read it now.
- Poster
Here we show that the combination of resolved methylation and genomic data combined with machine-learning can generate accurate inference of gene expression (both steady-state and nascent), chromatin accessibility, and enhancer state, demonstrating the key role of 5mC and 5hmC in gene regulation.
- Poster
This study shows that 5mC and 5hmC taken together are highly effective as biomarkers for early-stage CRC detection in cfDNA.
- Poster
Here we present duet evoC: an enzymatic method that reads the four canonical bases in DNA together with complete epigenetic information encoded in DNA - as applied to single cells.
- Poster
Formalin-fixed, paraffin-embedded (FFPE) specimens are commonly used for long-term storage in research and clinical settings, including immunohistochemistry, oncology, and genomics.
- Poster
Liquid biopsy for profiling of cell free DNA (cfDNA) in blood holds huge promise to transform how we experience and manage cancer by early detection and identification of residual disease and subtype.