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Published scientific research
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National Cancer Institute researchers show 6-base sequencing has the potential to transform liquid biopsy utility in informing clinical decisions without parallel tissue samples

6-base ctDNA 5mC/5hmC methylomics and clonal reconstruction infer tumour transcription and resistance phenotypes in metastatic prostate cancer

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Published scientific research
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Researchers at Johns Hopkins use duet evoC to reveal genetic and epigenetic mechanistic biomarkers of catastrophic antiphospholipid syndrome 

Integrated genetic and methylation analysis reveals how either mutational or epigenetic silencing drives disease 

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Published scientific research
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The importance of 5mC and 5hmC for biomarker discovery and biological insight is becoming clearer with the development of new methods for 6-base sequencing

This review covers the epigenetic influence of 5mC and 5hmC including recent findings connecting these modifications to disease processes and the potential of 6-base sequencing technologies to deepen our understanding of genetics and health.

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OGT prevents DNA demethylation and suppresses the expression of transposable elements in heterochromatin by restraining TET activity genome-wide
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OGT prevents DNA demethylation and suppresses the expression of transposable elements in heterochromatin by restraining TET activity genome-wide

Exciting news, Professor Anjana Rao’s lab at La Jolla Institute for Immunology has published a new study with Nature Structural & Molecular Biology. Learn how 6-base sequencing can reveal early biomarkers of genome dysfunction.

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Published scientific research
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Understanding the relationship between DNA methylation and genome dynamics

Assistant Professor Emily Hodges' lab at Vanderbilt University used differentiating neural stem cells as a model system to understand the relationship between DNA methylation and genome dynamics.

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Published scientific research
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Epigenome-wide DNA methylation association study

Learn how Associate Professor Alex Bick's lab at Vanderbilt University Medical Center conducted a multiracial meta-analysis of epigenome-wide association studies (EWAS) of Clonal Hematopoiesis of Indeterminate Potential (CHIP).

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5‑methylcytosine and 5‑hydroxymethylcytosine are synergistic biomarkers for early detection of colorectal cancer
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biomodal publication: Nature Communications Medicine. 5‑methylcytosine and 5‑hydroxymethylcytosine are synergistic biomarkers for early detection of colorectal cancer

Our study investigates the roles of 5‑methylcytosine (5mC) and 5‑hydroxymethylcytosine (5hmC) as biomarkers for early-stage colorectal cancer (CRC) detection in cell-free DNA (cfDNA).

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labs
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biomodal team published in Nature Biotechnology!

We are extremely proud to announce that our paper ‘Simultaneous sequencing of genetic and epigenetic bases in DNA’ has been published by the journal Nature Biotechnology.

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