26 June 2024
1:30 pm – 2:30 pm
Ryan Connolly Seminar Room
Zayed Centre for Research into Rare Disease
UCL Great Ormond Street Institute of Child Health
20 Guilford St
London, UK
Join Tim Beech, Product Manager, biomodal for a dynamic session. This seminar will introduce the 6-base genome (A, T, C, G, 5mC, and 5hmC) delivered by a powerful new technology, duet multiomics solution evoC. The added resolution of duet evoC will enable improved detection of disease associations, identification of novel biomarkers, development of disease classifiers, and monitoring the progression of disease.
We will discuss how the 6-base genome can improve the understanding of tumour biology from liquid biopsy
- Methylation states of enhancers in CRC cfDNA samples provide evidence that 5mC and 5hmC track cancer stage with greater precision.
- 6-base readouts provide two-dimensional methylation data that shows 5hmC variations that are associated with stage 1 vs healthy
High-level introduction into how 6-base genome data can be used to build models that accurately predict gene expression, chromatin accessibility, and enhancer status.
