Explore the role of DNA methylation in neurodegenerative diseases

How do 5mC and 5hmC impact neurodegenerative disease?

DNA methylation plays an essential role in neurobiology, controlling gene expression and regulation, which profoundly affects neurological health and disease progression.

Recent advances in neurobiology have uncovered the significant impact of DNA methylation in the development, progression, and potential treatment of various neurodegenerative, neurodevelopmental, and neuropsychiatric disorders. Research bridges genetics and environmental influences, offering insights into complex diseases like Alzheimer’s, Parkinson’s, Autism Spectrum Disorders, and Schizophrenia.

DNA methylation patterns are heritable and dynamic, responding to environmental cues such as stress, trauma, and chemicals. The methylation patterns also provide potential biomarkers of disease progression therapeutic targets. Interestingly, neuronal tissues are known to contain high levels of 5‑hydroxymethylcytosine (5hmC), an epigenetic marker that is typically only present in very low levels in most tissues.

Recent research has correlated differential methylation patterns to cancer and other disease where 5hmC has been shown to be a good indicator of diseases including glioblastoma. All of this indicates that the ability to accurately discriminate between 5‑methylcytosine (5mC) and 5hmC are crucial to understanding DNA methylation in neuronal tissues.

Neurodegenerative disease

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Discriminate between 5mC and 5hmC, whilst maintaining high genetic accuracy for the four standard bases. Achieve a full genome and methylome from low input DNA samples, investigate how those two modalities interact by measuring variant associated methylation, and identify differentially methylated regions by comparing results across experiments.

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