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Download the product sheet for modality XPLR today.
From global methylation patterns to differentially methylated regions, high-resolution data can help you get more from your studies.
Serial plasma dual 5mC/5hmC profiling moved liquid biopsy beyond mutation detection toward transcriptome-like tumor-state and resistance monitoring in mCRPC
The ssDNA duet workflow achieves ultra‑low limits of detection by combining high material recovery with outstanding sensitivity and specificity across genomic and epigenetic features.
We investigated the impact of a duet single stranded ligation workflow on methylation LoD (further details on duet single stranded ligation workflow are provided in poster #121) across duet +modC (which provides 5-base data) and duet evoC (which provides 6-base data, distinguishing between 5mC and 5mC).
We demonstrate the value of integrating genetic and epigenetic information from a single cfDNA assay using the duet evoC technology, which enables simultaneous extraction of complete genetics and complete epigenetics from the same sample.
Here, we assess the contribution of combined fragmentomic and epigenetic features to ctDNA detection in cfDNA from healthy individuals and colorectal cancer (CRC) patients.
Learn how 6‑base sequencing, which separates 5mC and 5hmC detection, reveals subtle early epigenetic changes that dramatically improve stage I colorectal cancer detection compared with traditional methylation methods.
6-base ctDNA 5mC/5hmC methylomics and clonal reconstruction infer tumour transcription and resistance phenotypes in metastatic prostate cancer
Integrated genetic and methylation analysis reveals how either mutational or epigenetic silencing drives disease 
This review covers the epigenetic influence of 5mC and 5hmC including recent findings connecting these modifications to disease processes and the potential of 6-base sequencing technologies to deepen our understanding of genetics and health.
biomodal, today announced at the AGBT 2026 General Meeting that biomodal’s duet multiomic solutions are compatible with Element Biosciences AVITI24™ 5D multiomics and AVITI™ sequencing instruments.

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