Resources
Resource types
- Poster
Measuring genetics, 5mC and 5hmC from the same DNA sample may provide a route to infer functional genomic information where direct RNA or chromatin profiling is not feasible.
- Poster
These findings show that accurate, independent measurement of 5mC and 5hmC provides a more complete and biologically informative view of differential methylation.
- Webinar
Connect variants to function with complete genetics and complete epigenetics
- Poster
The duet mosaic workflow meets the critical needs of liquid biopsy applications; complete and accurate phased multiomic features combined with recovery of the molecules that matter, resulting in ultra low LoD95 for ctDNA.
- Poster
Cell-free DNA (cfDNA) contains complementary genetic, epigenetic and fragmentomic signals that can inform cancer detection. However, these biomarkers are typically measured using separate assays, increasing sample input requirements, analytical complexity, and inter-assay variability.
- Poster
Circulating cell‑free DNA (cfDNA) contains rich genetic, epigenetic, and structural information for cancer detection, but its highly fragmented nature, low abundance, and high background noise make reliable detection of circulating tumour DNA (ctDNA) challenging.
- Webinar
Join us to learn how a single-stranded ligation approach preserves the native features of cfDNA by eliminating end-repair.
- Poster
The duet technology uses a hairpin approach to provide simultaneous, high accuracy genetics and epigenetics, including distinguishing 5hmC to 5mC. from a single low input sample.
- Publication
Here we utilize 6-base sequencing to profile DNA modifications of cell-free DNA released from neural cells into cerebrospinal fluid.
- Blog post
Six-base sequencing of cerebrospinal fluid cfDNA reads 5mC and 5hmC to detect neurological disease and reveal its biology, even when cfDNA can't be quantified.
- Product sheet
Maximize insight from every precious sample by using single-stranded ligation to read genetics, 5mC, 5hmC and fragmentomics from the same molecule. Ideal for cfDNA and liquid biopsy.
- News article
Distinguishing 5mC and 5hmC, enabled through duet evoC and the 6-base genome, delivered an AUC of 0.95 for stage I colorectal cancer from liquid biopsy, improving the earlier detection of stage I colorectal cancer from cfDNA samples!