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To address the difficulties of analysing methylation data, this poster presents modality, an efficient and scalable analysis package for 5- and 6-base genomes.
This poster demonstrates that the combination of 5mC and 5hmC is highly effective for early-stage CRC detection in cfDNA - read it now.
Understanding the factors that affect DNA methylation can open up new avenues to explore human health and disease.
Deoxyribonucleic acid, or DNA, is the fundamental building block of life. Let's explore the fascinating types of DNA in the world.
Robert Osborne, PhD, Senior Vice President of Research & Development provides a high-level overview of biomodal’s bioRXiv preprint, 5mC and 5hmC are synergistic biomarkers for early detection of colorectal cancer.
Liquid biopsy represents a groundbreaking advancement in disease diagnostics, offering a less invasive alternative to traditional tissue biopsies, particularly for cancer.
Our study investigates the roles of 5‑methylcytosine (5mC) and 5‑hydroxymethylcytosine (5hmC) as biomarkers for early-stage colorectal cancer (CRC) detection in cell-free DNA (cfDNA).
The utilisation of genetic biomarkers in liquid biopsy has caused a revolution in cancer diagnostics and personalised medicine.
Here we show that the combination of resolved methylation and genomic data combined with machine-learning can generate accurate inference of gene expression (both steady-state and nascent), chromatin accessibility, and enhancer state, demonstrating the key role of 5mC and 5hmC in gene regulation.
In part 2 of this webinar, Dr. Emily Hodges, assistant professor of biochemistry at Vanderbilt University, will reveal new data that illustrates how the Hodges Lab is utilising the 6-base genome.
Cambridge Epigenetix is now biomodal