Applications · Liquid biopsy

More insight from
every cfDNA sample.

Recover complete and accurate genetic, epigenetic and fragmentomic information from the same limited sample, to build a more complete view of the biology and achieve ultra-low limits of detection (LoD) in your liquid biopsy research.

cfDNA carries more information than
genetics alone

Each cfDNA molecule contains several layers of information. Studied together, these layers can provide complementary biomarkers of biological state, disease-associated processes and the origins of cfDNA.

Genetics

Sequence variants and copy
number changes

Identify sequence variation associated with disease, clonal populations or inherited biology, including low-frequency variants.

Epigenetics

Cytosine modifications

Measure DNA modifications that reflect regulatory state, cellular identity and biological activity beyond the underlying sequence.

Fragmentomics

Native fragment features preserved

Preserve native fragment characteristics and investigate structural patterns that may provide an additional source of biological signal.

See why native cfDNA features matterExplore how preserving fragment characteristics can improve liquid biopsy analysis.
Watch the webinar →

Current approaches
limit your research

cfDNA is precious, fragmented and often available at low input. Current approaches can force researchers to compromise by:

  1. 01
    Splitting the sampleSeparate assays consume limited material and can make direct integration more difficult.
  2. 02
    Prioritizing one signalA genetics-first or methylation-first workflow leaves complementary molecular information unused.
  3. 03
    Compromising accuracyLower accuracy can obscure rare signals and limit your ability to detect disease-derived DNA at very low levels.
  4. 04
    Losing difficult fragmentsShort or damaged molecules may not be captured by workflows built for intact double-stranded cfDNA.
  5. 05
    Combining disconnected dataSeparate workflows create additional analytical and operational complexity by forcing you to combine datasets.
The duet mosaic portfolio

With duet mosaic, you don't have to choose

The duet mosaic portfolio is designed to get more from limited cfDNA, bringing high accuracy and complete genetic, epigenetic and fragmentomic information together in a single workflow to achieve ultra-low LoD.

Start with one low-input sample

Make more of precious cfDNA without splitting limited material across separate assays.

Capture more of the cfDNA that's there

Single-stranded ligation improves recovery of short, damaged and single-stranded fragments that are otherwise lost.

Get the complete multiomic picture

Read genetics, epigenetics and fragmentomics together from the same DNA molecule, rather than prioritizing one signal at the expense of another.

Work from one integrated dataset

Bring complementary molecular information together without having to reconcile outputs from separate workflows.

Detect what others miss

High accuracy, more complete molecular information and improved fragment recovery combine to support ultra-low limits of detection, helping reveal rare disease-derived cfDNA that might otherwise be missed.

Ask richer
questions
of cfDNA

Identify and evaluate combinations of genetic, epigenetic and fragmentomic features associated with a biological state or disease process.

cfDNA can provide a window into disease biology

Oncology

Cancer research

Detect rare ctDNA at ultra-low LoDs by combining genetic, epigenetic and fragmentomic signals, supporting research in early cancer detection, MCED, MRD and longitudinal disease monitoring.

Neurology

Neurological research

Identify novel biomarkers from plasma or cerebrospinal fluid cfDNA to better detect and understand neurological disease.

Alternative cfDNA sources

Identify biomarkers from alternative sources of cfDNA

See how 6-base sequencing profiles cerebrospinal fluid cfDNA in neurological liquid biopsy research.

Read the research

See what multiomic cfDNA analysis can reveal

Explore research and on-demand sessions spanning native cfDNA feature preservation, neurological liquid biopsy, treatment resistance and early-stage cancer biomarker discovery.

All resources
Webinar on demand

Preserve more of what cfDNA can tell you

Learn why preserving native cfDNA features matters for achieving ultra-low LoD and fragment-level liquid biopsy analysis.

Watch the webinar →
Neurological research

6-base sequencing of cerebrospinal fluid cfDNA

Explore neurological liquid biopsy research using cfDNA released from neural cells into cerebrospinal fluid.

Read the research →
Webinar on demand

Reveal resistance mechanisms in prostate cancer

See how serial plasma cfDNA and 6-base sequencing were used to investigate tumour phenotypes and resistance patterns over time.

Watch the webinar →
Publication

Separate 5mC and 5hmC for better detection of colorectal cancer

Explore evidence for 5mC and 5hmC as synergistic cfDNA biomarkers for early-stage colorectal cancer detection.

Read the publication summary →

Explore the right solution for
your cfDNA research

Choose the level of epigenetic resolution that best fits your biological question.

duet +modC mosaic kit and software
duet +modC mosaic

Generate genetic, modified cytosine and native fragmentomic information from limited cfDNA through one streamlined workflow.

duet 6-base mosaic kit and software
duet 6-base mosaic

Resolve genetics, 5mC, 5hmC and fragmentomics independently from the same limited cfDNA sample.

High-confidence genetic information✓✓
Cytosine modification readoutModified cytosine measurementIndependent 5mC and 5hmC resolution
Native fragment characteristics✓✓
Designed for low-input cfDNA✓✓
A strong fit when ……integrated genetics, modC and fragmentomics answer the study question.…biologically distinct 5mC and 5hmC signals are important to the research question.
Explore duet +modC mosaicExplore duet 6-base mosaic
duet +modC mosaic kit and software

duet +modC mosaic

Generate genetic, modified cytosine and native fragmentomic information from limited cfDNA through one streamlined workflow.

  • High-confidence genetic information✓
  • Cytosine modification readoutModified cytosine measurement
  • Native fragment characteristics✓
  • Designed for low-input cfDNA✓

A strong fit when … integrated genetics, modC and fragmentomics answer the study question.

Explore duet +modC mosaic
duet 6-base mosaic kit and software

duet 6-base mosaic

Resolve genetics, 5mC, 5hmC and fragmentomics independently from the same limited cfDNA sample.

  • High-confidence genetic information✓
  • Cytosine modification readoutIndependent 5mC and 5hmC resolution
  • Native fragment characteristics✓
  • Designed for low-input cfDNA✓

A strong fit when … biologically distinct 5mC and 5hmC signals are important to the research question.

Explore duet 6-base mosaic

What could you learn from the cfDNA you already have?

Talk with a biomodal scientist about your sample type, input, biological question and the level of multiomic resolution your study requires.

Talk to a scientist

What are you looking for?