In part 2 of this webinar, Emily Hodges, PhD, assistant professor of biochemistry at Vanderbilt University, will reveal new data that illustrates how the Hodges Lab is utilising the 6-base genome to investigate the dynamics of enhancer DNA methylation during cellular differentiation.
Dr. Hodges will discuss how the advanced 6-base genome solution, duet multiomics solution evoC, provided a multidimensional view that allowed the team to investigate the correlation of methylation state and chromatin accessibility at specific sites across the genome.
Specifically:
- Genome-wide detection of 5-hydroxymethylcytosine revealed active demethylation begins ahead of chromatin and transcription factor activity, while enhancer hypomethylation persists long after these activities have dissipated.
- Timepoint-specific methylation states predict past, present and future chromatin accessibility using machine learning models.
This webinar is a two-part series. If you haven’t watched part one yet, then do that now.
