Learn more about achieving simultaneous genetic and epigenetic profiles from cell-free DNA.
duet multiomics solution evoC investigates the 6-base genome, providing sequencing data on the four canonical bases (A, C, G, and T) whilst differentiating 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC). This is achieved using a low input cfDNA sample of only 5ng.
The multiomic output allows for determination of cfDNA fragment size, Copy Number Variation information, differentially methylated regions, and variant-associated methylation, and achieves superior genetic and epigenetic accuracy throughout. It also facilitates discovery of new, inaccessible biomarkers using the discrete 5mC and 5hmC information, allowing earlier detection of biological changes in patient samples.