Blog
What factors determine DNA methylation?
Understanding the factors that affect DNA methylation can open up new avenues to explore human health and disease.
18 February 2025
News
Blog
Types of DNA: a comprehensive overview of DNA structures
Deoxyribonucleic acid, or DNA, is the fundamental building block of life. Let’s explore the fascinating types of DNA in the world.
22 January 2025
Blog
Liquid biopsy: unveiling methylation biomarkers for early cancer diagnosis
Liquid biopsy represents a groundbreaking advancement in disease diagnostics, offering a less invasive alternative to traditional tissue biopsies, particularly for cancer.
16 December 2024
News
Read our bioRXiv preprint: 5‑methylcytosine and 5‑hydroxymethylcytosine are synergistic biomarkers for early detection of colorectal cancer
Our study investigates the roles of 5‑methylcytosine (5mC) and 5‑hydroxymethylcytosine (5hmC) as biomarkers for early-stage colorectal cancer (CRC) detection in cell-free DNA (cfDNA).
25 November 2024
Blog
How liquid biopsy utilises genetic biomarkers for early diagnosis
The utilisation of genetic biomarkers in liquid biopsy has caused a revolution in cancer diagnostics and personalised medicine.
18 November 2024
Posters
Inferring genome organisation and gene regulation from 6-base sequencing data
Here we show that the combination of resolved methylation and genomic data combined with machine-learning can generate accurate inference of gene expression (both steady-state and nascent), chromatin accessibility, and enhancer state, demonstrating the key role of 5mC and 5hmC in gene regulation.
8 November 2024
Posters
Simultaneous single cell sequencing of genetic and epigenetic bases
Here we present duet evoC: an enzymatic method that reads the four canonical bases in DNA together with complete epigenetic information encoded in DNA – as applied to single cells.
6 November 2024
Posters
Multiomic 6-base data from cell-free DNA enhances the performance of liquid biopsy classifiers
This study shows that 5mC and 5hmC taken together are highly effective as biomarkers for early-stage CRC detection in cfDNA.
6 November 2024
Blog
How histone modifications impact gene regulation
histone modifications play a crucial role in regulating gene expression and chromatin structure. These modifications work together in complex patterns to fine-tune cellular processes.
4 November 2024
News
biomodal to present new 6-base genome data showing enhanced sensitivity for detection of stage I colorectal cancer in plasma cell-free DNA at American Society of Human Genetics meeting 2024
“Our goal is to provide researchers and liquid biopsy clinical test developers with innovative tools that enable them to reveal previously undetectable biological changes,”
1 November 2024
