Blog
Understanding the role of CpG islands in gene regulation
Understanding how alterations in CpG island methylation contribute to disease states, including cancer, may provide novel targets for treatment.
12 September 2025
News
Posters
Inferring gene regulation from 6-base sequencing data
Patterns of 5hmC and 5hmC provide a view on tissue-specific gene expression.
16 July 2025
Posters
Synergy with decitabine expands the utility of talazoparib: A novel therapeutic strategy for BRCA-proficient pancreatic cancer
The combination of PARPi (Talazoparib – TAL) and DNMTi (Decitabine – DAC) functions synergistically to inhibit PCa cell lines and patient-derived PTOs.
10 July 2025
Posters
Mechanisms of resistance to PD-L1/PARP1-targeted therapy in metastatic castration-resistant prostate cancer inferred by liquid biopsy
Circulating tumor DNA (ctDNA) purity can be used to predict therapy response of metastatic castration-resistant prostate cancer (mCRPC) to PD-L1/PARP1 inhibition.
9 July 2025
Posters
A high-performance toolkit for large-scale analysis of 5- and 6-base genomes
We present a computational toolkit to analyse 5mC and 5hmC modifications at scale and describe its performance on a novel liquid biopsy dataset.
24 April 2025
News
Fox Chase Cancer Center’s Cancer Epigenetics Institute to Present Data From Ongoing Collaboration at biomodal Workshop at AACR Annual Meeting
Alfonso Bellacosa, MD, PhD, a Professor in the Nuclear Dynamics and Cancer Research Program and Johnathan R. Whetstine, PhD, the Jack Schultz Chair in Basic Science, both at Fox Chase.
17 April 2025
Posters
Assessment of ctDNA detection in localised prostate cancer using a multiomics approach
Professor Ellen Heitzer’s lab at the Medical University of Graz analysed eight samples from localised PCa, metastatic PCa, and suspicious Pca (men with elevated serum PSA and/or suspect digital rectal examination but negative biopsy) using the duet multiomics solution evoC.
28 March 2025
News
The ‘six-base genome’ sheds light on hidden cancer dynamics
As well as helping researchers identify tumour DNA amid the soup of regular cell-free DNA, the fact that different tissues have distinct methylation patterns can help explain where the cell-free DNA might be coming from. “There are many advantages to being able to study epigenomics in concert with genomic features,” says Dawson.
24 March 2025
Posters
OGT prevents DNA demethylation and suppresses the expression of transposable elements in heterochromatin by restraining TET activity genome-wide
Learn how 6-base sequencing reveals 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC) have important roles in the regulation of genome dynamics. Deregulation of TET can spur an increase of 5hmC in heterochromatin which could potentially be an early biomarker of genome dysfunction that lead to diseases.
12 March 2025
Posters
Multiomic 6-base sequencing enhances the performance of early colorectal cancer detection from cell-free DNA
Download this poster Credits Fabio Puddu¹ Annelie Johansson¹ Aurélie Modat¹ Jamie Scotcher¹ Riccha Sethi¹ Nick Harding¹ Mark Hill¹ Ermira Lleshi¹ Casper Lumby¹ Jean Teyssandier¹ Michael
12 March 2025