• Symposium
  • biomodal presenter
  • In partnership with Illumina

CRC-STARS 1st Annual Meeting

Don’t miss out when Ryan Hull presents “5-methylcytosine and 5-hydroxymethylcytosine are synergistic biomarkers for early detection of colorectal cancer.” 
2 February 2026
9:00 am
to 5:00 pm
GMT
The Exchange, Assembly Room
, Birmingham
, United Kingdom

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About the event

Welcome to the CRC-STARS 1st Annual Meeting! Join us at The Exchange, Birmigham for a day filled with networking, discussions, and collaboration. This in-person event is a great opportunity to connect with other members of the consortium. Don’t miss out on the chance to share ideas, hear about different aspects of the project, and build relationships.

Presenting at the event

5-methylcytosine and 5-hydroxymethylcytosine are synergistic biomarkers for early detection of colorectal cancer

Ryan Hull

Field Application Scientist - UK, Ireland & Nordics

biomodal

2.57pm - 3.06pm

Early cancer detection has the potential to significantly improve treatment outcomes and survival rates. This study investigates the roles of 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC) as biomarkers for early-stage colorectal cancer (CRC) detection in cell-free DNA (cfDNA). We show that models combining measurements of 5mC and 5hmC significantly enhance diagnostic accuracy (AUC=0.95) compared to traditional approaches. Of all the DMRs considered, almost half show an increase in 5hmC at stage I, and a corresponding decrease in 5mC at stage IV, suggesting that 5hmC can effectively track regions undergoing demethylation during tumour development. These results support the hypothesis that distinguishing between 5mC and 5hmC improves the sensitivity of liquid biopsy tests for early-stage cancer detection.

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One sample. One workflow. One solution.

Here are the relevant biomodal resources for information. Find poster presentation information, case studies, interviews, and more.

Cancer research

Discover how alterations in DNA methylation play a crucial role in cancer research via gene expression changes and mutation occurrence. Learn more.

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Attending from biomodal

Leonardo Motta

Leonardo Motta

Territory Account Manager – UK, Ireland & Nordics
Ryan Hull

Ryan Hull, PhD

Field Application Scientist – UK, Ireland & Nordics

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Meet our team at the event

CRC-STARS 1st Annual Meeting 2FEB26
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