Reveal the power of the 6-base genome.
Join us for a special journal club at Moffitt Cancer Center highlighting discoveries utilizing combined genetic and epigenetic technology at single-base-resolution. We will review discoveries utilizing data that reveals standard four-base sequencing (A, C, G, and T), and distinguishes between 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC) simultaneously in a single sample preparation.
This added resolution allows greater power in detecting disease associations, identifying novel biomarkers, developing disease classifiers, and monitoring the progression of disease; even with limited or difficult samples such as FFPE and cell-free DNA (cfDNA).
Publication reviews will include:
- Simultaneous sequencing of genetic and epigenetic bases in DNA. Füllgrabe, J., Gosal, W.S., Creed, P. et al. Simultaneous sequencing of genetic and epigenetic bases in DNA. Nat Biotechnol 41, 1457–1464 (2023).
- 5-methylcytosine and 5-hydroxymethylcytosine are synergistic biomarkers for early detection of colorectal cancer. Fabio Puddu, Annelie Johansson, Aurélie Modat, Jamie Scotcher, Riccha Sethi, Shirong Yu, Nick Harding, Mark Hill, Ermira Lleshi, Casper Lumby, Jean Teyssandier, Michael Wilson, Robert Crawford, Tom Charlesworth, Robert J Osborne, Shankar Balasubramanian, Páidí Creed. bioRxiv 2024.10.30.621123
12:30 PM – 1:30 PM
Moffitt Cancer Center
MRC4084
12902 USF Magnolia Drive
Tampa, FL 33612
