Join us for a special journal club seminar at St. Jude highlighting discoveries utilizing combined genetic and epigenetic technology at single-base-resolution. We will review discoveries utilizing data that reveals standard four-base sequencing (A, C, G, and T), and distinguishes between 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC) simultaneously in a single sample preparation.
This added resolution allows greater power in detecting disease associations, identifying novel biomarkers, developing disease classifiers, and monitoring the progression of disease; even with limited samples such as cell-free DNA (cfDNA).
Publication reviews will include:
- Simultaneous sequencing of genetic and epigenetic bases in DNA. Füllgrabe, J., Gosal, W.S., Creed, P. et al. Simultaneous sequencing of genetic and epigenetic bases in DNA. Nat Biotechnol 41, 1457–1464 (2023).
- 5-methylcytosine and 5-hydroxymethylcytosine are synergistic biomarkers for early detection of colorectal cancer. Fabio Puddu, Annelie Johansson, Aurélie Modat, Jamie Scotcher, Riccha Sethi, Shirong Yu, Nick Harding, Mark Hill, Ermira Lleshi, Casper Lumby, Jean Teyssandier, Michael Wilson, Robert Crawford, Tom Charlesworth, Robert J Osborne, Shankar Balasubramanian, Páidí Creed. bioRxiv 2024.10.30.621123
- OGT prevents DNA demethylation and suppresses the expression of transposable elements in heterochromatin by restraining TET activity genome-wide. Sepulveda, H., Li, X., Arteaga-Vazquez, L.J. et al. OGT prevents DNA demethylation and suppresses the expression of transposable elements in heterochromatin by restraining TET activity genome-wide. Nat Struct Mol Biol (2025).
St. Jude Advanced Research Center
Room ARC M1110
612 St Jude Pl
Memphis, TN 38105
1:30PM – 2:30PM
Speaker: Thao Huynh, MMA. Field Application Scientist. thao.huynh@biomodal.com
Questions? Contact Christine Hipsky, Territory Account Manager, MS. christine.hipsky@biomodal.com
