Distinguish 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC) together with all 4 canonical bases to measure multiple modes of biology from a single low-input DNA sample in a single experiment. The 6-base genome enables multidimensional DNA methylation analysis for biomarker discovery to gain transformative insights into current and future states of disease.
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Here are the relevant biomodal resources for information. Find poster presentation information, case studies, interviews, and more.
Unlock the power of the 6-base genome with duet evoC data, providing unprecedented insight, including A, C, G, T plus 5mC and 5hmC, in a single read. Learn more
Download this poster Credits Sabri Jamal Nicholas Harding Jean Teyssandier Michael J. Wilson Gary Frewin Nicola Wong William Stark Mark S. Hill Páidí Creed biomodal
Download this poster Credits Fabio Puddu¹ Annelie Johansson¹ Aurélie Modat¹ Jamie Scotcher¹ Riccha Sethi¹ Nick Harding¹ Mark Hill¹ Ermira Lleshi¹ Casper Lumby¹ Jean Teyssandier¹ Michael
Here we show that the combination of resolved methylation and genomic data combined with machine-learning can generate accurate inference of gene expression (both steady-state and nascent), chromatin accessibility, and enhancer state, demonstrating the key role of 5mC and 5hmC in gene regulation.
FFPE cancer samples are an incredibly important and clinically relevant information source for directly studying the causes and consequences of the disease. This technical note shows how duet evoC can identify DNA methylation markers from FFPE samples.
