This Teach Me in 10 will introduce the 6‑base genome (A, T, C, G, 5mC, and 5hmC) delivered by a powerful new technology, duet multiomics solution evoC. The added resolution of duet evoC will enable improved detection of disease associations, identification of novel biomarkers, development of disease classifiers, and monitoring of disease progression.
In this episode, we will discuss:
How the 6-base genome can improve the understanding of tumour biology from liquid biopsy:
- Methylation states of enhancers in CRC cfDNA samples provide evidence that 5mC and 5hmC track cancer stage with greater precision.
- 6-letter readouts provide two-dimensional methylation data that shows 5hmC variations that are associated with stage 1 vs healthy
High-level introduction into how 6‑base genome data can be used to build models that accurately predict gene expression, chromatin accessibility, and enhancer status
