Most transposable elements (TE) lay dormant, buried under repressive epigenetic marks that ensure their influence over cell behaviour remains minimal. When they awaken, however, the consequences can be far reaching.
Professor Ellen Heitzer’s lab at the Medical University of Graz analysed eight samples from localised PCa, metastatic PCa, and suspicious Pca (men with elevated serum PSA and/or suspect digital rectal examination but negative biopsy) using the duet multiomics solution evoC.
Exciting news, Professor Anjana Rao’s lab at La Jolla Institute for Immunology has published a new study with Nature Structural & Molecular Biology. Learn how 6-base sequencing can reveal early biomarkers of genome dysfunction.
In this preprint, Assistant Professor Emily Hodges’ lab at Vanderbilt University used differentiating neural stem cells as a model system to understand the relationship between DNA methylation and genome dynamics.
In this preprint, learn how Associate Professor Alex Bick’s lab at Vanderbilt University Medical Center conducted a multiracial meta-analysis of epigenome-wide association studies (EWAS) of Clonal Hematopoiesis of Indeterminate Potential (CHIP).
As well as helping researchers identify tumour DNA amid the soup of regular cell-free DNA, the fact that different tissues have distinct methylation patterns can help explain where the cell-free DNA might be coming from. “There are many advantages to being able to study epigenomics in concert with genomic features,” says Dawson.
Download this poster Credits Fabio Puddu¹ Annelie Johansson¹ Aurélie Modat¹ Jamie Scotcher¹ Riccha Sethi¹ Nick Harding¹ Mark Hill¹ Ermira Lleshi¹ Casper Lumby¹ Jean Teyssandier¹ Michael
Learn how 6-base sequencing reveals 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC) have important roles in the regulation of genome dynamics. Deregulation of TET can spur an increase of 5hmC in heterochromatin which could potentially be an early biomarker of genome dysfunction that lead to diseases.
To address the difficulties of analysing methylation data, this poster presents modality, an efficient and scalable analysis package for 5- and 6-base genomes.
This poster demonstrates that the combination of 5mC and 5hmC is highly effective for early-stage CRC detection in cfDNA – read it now.
