Blog
How liquid biopsy utilises genetic biomarkers for early diagnosis
The utilisation of genetic biomarkers in liquid biopsy has caused a revolution in cancer diagnostics and personalised medicine.
18 November 2024
News
Posters
Inferring genome organisation and gene regulation from 6-base sequencing data
Here we show that the combination of resolved methylation and genomic data combined with machine-learning can generate accurate inference of gene expression (both steady-state and nascent), chromatin accessibility, and enhancer state, demonstrating the key role of 5mC and 5hmC in gene regulation.
8 November 2024
Posters
Simultaneous single cell sequencing of genetic and epigenetic bases
Here we present duet evoC: an enzymatic method that reads the four canonical bases in DNA together with complete epigenetic information encoded in DNA – as applied to single cells.
6 November 2024
Posters
Multiomic 6-base data from cell-free DNA enhances the performance of liquid biopsy classifiers
This study shows that 5mC and 5hmC taken together are highly effective as biomarkers for early-stage CRC detection in cfDNA.
6 November 2024
Blog
How histone modifications impact gene regulation
histone modifications play a crucial role in regulating gene expression and chromatin structure. These modifications work together in complex patterns to fine-tune cellular processes.
4 November 2024
News
biomodal to present new 6-base genome data showing enhanced sensitivity for detection of stage I colorectal cancer in plasma cell-free DNA at American Society of Human Genetics meeting 2024
“Our goal is to provide researchers and liquid biopsy clinical test developers with innovative tools that enable them to reveal previously undetectable biological changes,”
1 November 2024
Blog
cfDNA fragmentomics: the next frontier in genetic testing
By analysing the unique fragmentation patterns of cfDNA, researchers are unlocking new possibilities for early disease detection, including cancer and prenatal testing. This cutting-edge field combines insights from epigenetics and nucleosome positioning to develop sensitive diagnostic tools that could transform healthcare.
28 October 2024
Blog
What is epigenetics? A brief introduction into how & why our genes switch on and off
Discover the fascinating world of epigenetics, where our genes are influenced not only by our DNA but also by our environment.
22 October 2024
Blog
How liquid biopsy is transforming neurodegenerative disease diagnosis
Explore how liquid biopsy works for neurodegenerative disease diagnosis; including advantages over traditional methods and promising biomarkers.
7 October 2024
Blog
Redefining 5hmC: more than just a stepping stone in the DNA demethylation pathway
5hmC is far more than just a transient step in the DNA demethylation pathway as it has broad implications for gene regulation, cellular differentiation, brain function, genome stability, and disease.
29 August 2024
