Epigenome-wide DNA methylation association study of CHIP provides insight into perturbed gene regulation
Within the Division of Genetic Medicine at Vanderbilt University Medical Center, Associate Professor Alex Bick’s lab is expanding the limits of our understanding of Clonal Hematopoiesis of Indeterminate Potential (CHIP).
In this preprint, learn how researchers conducted a multiracial meta-analysis of epigenome-wide association studies (EWAS) of CHIP and its subtypes in four cohorts (N=8196) to elucidate the molecular mechanisms underlying CHIP and illuminate how these changes influence cardiovascular disease risk. The EWAS findings were functionally validated using human hematopoietic stem cell (HSC) models of CHIP. Validating data used engineered ESCs with specific DNA methylation gene edits to mimic the disease that were differentiated, sorted and analysed using duet evoC to understand DNA methylation patterns.
