Rao Lab, DNA Methylation, epigenetics, publication

OGT prevents DNA demethylation and suppresses the expression of transposable elements in heterochromatin by restraining TET activity genome-wide

Research paper shows 6-base sequencing can reveal early biomarkers of genome dysfunction that lead to diseases

Exciting news, Professor Anjana Rao’s Lab at La Jolla Institute for Immunology has published a new study with Nature Structural & Molecular Biology. Read more to learn how 6-base sequencing reveals:

  • 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC) have important roles in the regulation of genome dynamics 
  • Deregulation of TET can spur an increase of 5hmC in heterochromatin which could potentially be an early biomarker of genome dysfunction that leads to diseases

This is groundbreaking insight into the power of the 6-base genome!

Read the full research paper.

Read the blog.

Learn more about duet evoC.

Keep reading

Cambridge Epigenetix is now biomodal