Blog
What factors determine DNA methylation?
Understanding the factors that affect DNA methylation can open up new avenues to explore human health and disease.
12 September 2025
News
Blog
Redefining 5hmC: more than just a stepping stone in the DNA demethylation pathway
5hmC is far more than just a transient step in the DNA demethylation pathway as it has broad implications for gene regulation, cellular differentiation, brain function, genome stability, and disease.
12 September 2025
Blog
Epigenetics: unlocking the secrets of gene regulation
Explore the fascinating world of the different types of epigenetic modifications and the role of epigenetics in gene expression. Learn more.
12 September 2025
Blog
The role of heterochromatin in genome organisation
Heterochromatin is a condensed form of chromatin that plays an essential role in maintaining genomic stability. Disruptions in its formation can lead to disease. We explore the mysteries of heterochromatin and its vital role in genome organisation.
12 September 2025
Blog
Understanding the role of CpG islands in gene regulation
Understanding how alterations in CpG island methylation contribute to disease states, including cancer, may provide novel targets for treatment.
12 September 2025
Posters
Inferring gene regulation from 6-base sequencing data
Patterns of 5hmC and 5hmC provide a view on tissue-specific gene expression.
16 July 2025
Posters
Synergy with decitabine expands the utility of talazoparib: A novel therapeutic strategy for BRCA-proficient pancreatic cancer
The combination of PARPi (Talazoparib – TAL) and DNMTi (Decitabine – DAC) functions synergistically to inhibit PCa cell lines and patient-derived PTOs.
10 July 2025
Posters
Mechanisms of resistance to PD-L1/PARP1-targeted therapy in metastatic castration-resistant prostate cancer inferred by liquid biopsy
Circulating tumor DNA (ctDNA) purity can be used to predict therapy response of metastatic castration-resistant prostate cancer (mCRPC) to PD-L1/PARP1 inhibition.
9 July 2025
Posters
A high-performance toolkit for large-scale analysis of 5- and 6-base genomes
We present a computational toolkit to analyse 5mC and 5hmC modifications at scale and describe its performance on a novel liquid biopsy dataset.
24 April 2025
News
Fox Chase Cancer Center’s Cancer Epigenetics Institute to Present Data From Ongoing Collaboration at biomodal Workshop at AACR Annual Meeting
Alfonso Bellacosa, MD, PhD, a Professor in the Nuclear Dynamics and Cancer Research Program and Johnathan R. Whetstine, PhD, the Jack Schultz Chair in Basic Science, both at Fox Chase.
17 April 2025