This poster demonstrates that the combination of 5mC and 5hmC is highly effective for early-stage CRC detection in cfDNA – read it now.
Understanding the factors that affect DNA methylation can open up new avenues to explore human health and disease.
Deoxyribonucleic acid, or DNA, is the fundamental building block of life. Let’s explore the fascinating types of DNA in the world.
Liquid biopsy represents a groundbreaking advancement in disease diagnostics, offering a less invasive alternative to traditional tissue biopsies, particularly for cancer.
Our study investigates the roles of 5‑methylcytosine (5mC) and 5‑hydroxymethylcytosine (5hmC) as biomarkers for early-stage colorectal cancer (CRC) detection in cell-free DNA (cfDNA).
The utilisation of genetic biomarkers in liquid biopsy has caused a revolution in cancer diagnostics and personalised medicine.
Here we show that the combination of resolved methylation and genomic data combined with machine-learning can generate accurate inference of gene expression (both steady-state and nascent), chromatin accessibility, and enhancer state, demonstrating the key role of 5mC and 5hmC in gene regulation.
Here we present duet evoC: an enzymatic method that reads the four canonical bases in DNA together with complete epigenetic information encoded in DNA – as applied to single cells.
This study shows that 5mC and 5hmC taken together are highly effective as biomarkers for early-stage CRC detection in cfDNA.
histone modifications play a crucial role in regulating gene expression and chromatin structure. These modifications work together in complex patterns to fine-tune cellular processes.
