Blog
How liquid biopsy utilises genetic biomarkers for early diagnosis
The utilisation of genetic biomarkers in liquid biopsy has caused a revolution in cancer diagnostics and personalised medicine.
18 November 2024
News
Posters
Inferring genome organisation and gene regulation from 6-base sequencing data
Here we show that the combination of resolved methylation and genomic data combined with machine-learning can generate accurate inference of gene expression (both steady-state and nascent), chromatin accessibility, and enhancer state, demonstrating the key role of 5mC and 5hmC in gene regulation.
8 November 2024
Posters
Multiomic 6-base data from cell-free DNA enhances the performance of liquid biopsy classifiers
This study shows that 5mC and 5hmC taken together are highly effective as biomarkers for early-stage CRC detection in cfDNA.
6 November 2024
Posters
Simultaneous single cell sequencing of genetic and epigenetic bases
Here we present duet evoC: an enzymatic method that reads the four canonical bases in DNA together with complete epigenetic information encoded in DNA – as applied to single cells.
6 November 2024
Blog
How histone modifications impact gene regulation
Discover how histone modifications like acetylation and methylation shape chromatin structure, control gene expression, and influence epigenetic regulation.
4 November 2024
News
biomodal to present new 6-base genome data showing enhanced sensitivity for detection of stage I colorectal cancer in plasma cell-free DNA at American Society of Human Genetics meeting 2024
“Our goal is to provide researchers and liquid biopsy clinical test developers with innovative tools that enable them to reveal previously undetectable biological changes,”
1 November 2024
Blog
What is epigenetics? A brief introduction into how & why our genes switch on and off
Discover the fascinating world of epigenetics, where our genes are influenced not only by our DNA but also by our environment.
22 October 2024
Blog
How liquid biopsy is transforming neurodegenerative disease diagnosis
Explore how liquid biopsy works for neurodegenerative disease diagnosis; including advantages over traditional methods and promising biomarkers.
7 October 2024
Blog
How DNA methylation affects gene expression
DNA methylation serves as a pivotal epigenetic mechanism that significantly influences gene regulation by recruiting proteins that facilitate gene repression or by hindering transcription factors
19 August 2024
Blog
Understanding genomic DNA (gDNA): unravelling the blueprint of life
The study of genomic DNA (gDNA) has revolutionised the field of genetics, allowing scientists to gain a deeper understanding of how traits are inherited and how genetic variations contribute to disease.
24 July 2024