Integrate multiple modes of biology from a single sample in a single experiment to provide transformative insights into health and disease.
Introducing modality XPLR v1.1.0 with modality Viewer (beta)
An intuitive new solution for exploring 6-base analysis
Current technologies are unable to reliably resolve both genetic and epigenetic sequences at low sample input and miss important information. biomodal’s duet multiomics solution evoC gives you access to the 6-base genome – all four canonical bases and distinguishes 5‑methylcytosine (5mC) and 5‑hydroxymethylcytosine (5hmC) – from a single 5ng DNA sample, in a single experiment, with high accuracy.
Combined epigenetic and genetic analysis in a single sequencing run lets you access the most critical information from your DNA samples.
Better characterise liquid biopsy and genomic DNA samples of early stage cancer for diagnostic and therapy development.
Combined data reveals the role of methylation in neurodegeneration.
Pinpoint epigenetic changes that determine patterns of disease and health throughout a lifespan.
Improved DNA-based diagnostics with the ability to see disease-relevant changes from low input samples
Detect minute epigenetic changes to better understand maternal and foetal health.
A true 6-base genome that distinguishes 5mC and 5hmC together with all four canonical bases to measure multiple modes of biology
Assess all four canonical bases plus modified cytosine
Six-base sequencing of cerebrospinal fluid cfDNA reads 5mC and 5hmC to detect neurological disease and reveal its biology, even when cfDNA can’t be quantified.
Distinguishing 5mC and 5hmC, enabled through duet evoC and the 6-base genome, delivered an AUC of 0.95 for stage I colorectal cancer from liquid biopsy, improving the earlier detection of stage I colorectal cancer from cfDNA samples!
We evaluated 6-base sequencing with duet evoC, which simultaneously profiles 5mC, 5hmC, genetic variants and fragmentomics features from a single cfDNA sample.
We can help you reveal new data and multimodal insights from your research.
