International Society for Computational Biology

Reveal the power of the 6-base genome. Introducing duet multiomics solution evoC. Distinguish 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC) together with all four canonical bases to measure multiple modes of biology from a single low-input DNA sample in a single experiment. Identify novel multimodal biomarkers to gain transformative insights into current and future states of disease.
20 July 2025
to 24 July 2025
Online
, Liverpool
, United Kingdom

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About the event

The annual international conference on Intelligent Systems for Molecular Biology (ISMB) is the flagship meeting of the International Society for Computational Biology (ISCB). The 2025 meeting is the 33rd ISMB conference, which has grown to become the world’s largest bioinformatics and computational biology conference. Joining forces with the European Conference on Computational Biology (the 24th Annual Conference), ISMB/ECCB 2025 will be the year’s most important computational biology event!

The international meeting will be held in-person at the ACC Liverpool—a leading conference and event venue in the UK—and virtually through ISCB’s Nucleus platform.

Presenting at the event

Inferring gene regulation from 6-base sequencing data

Nicola Wong

Data Scientist - Bioinformatics

biomodal

ISMB - 20th - 24th July

DNA methylation, an epigenetic modification, plays a key role in the  regulation of gene expression. Specifically, the addition of a methyl group to  the 5th carbon of cytosine (5mC) is broadly associated with transcriptional  repression, with patterns of methylation established during cell fate  determination constraining the transcriptional programs in cells.  Demethylation via oxidation of 5- methylcytosine to 5- hydroxymethylcytosine  (5hmC) is performed by TET enzymes and is reflected by higher levels of  5hmC in the gene bodies of actively transcribed genes and at active or  lineage- specific enhancers.

Find the venue

One sample. One workflow. One solution.

Here are the relevant biomodal resources for information. Find poster presentation information, case studies, interviews, and more.

Related resources

Attending from biomodal

Leonardo Motta

Leonardo Motta

Territory Account Manager – UK, Ireland & Nordics

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ISMB 20JUL25
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