Resources
Resource types
- Blog post
Discover how DNA stores multimodal information through a process known as DNA methylation and its crucial role in gene expression and regulation.
- Blog post
The 6-base genome expands our understanding of genetics by incorporating both genetic & epigenetic data to get a clearer picture of health and disease biology.
- Blog post
By analysing the unique fragmentation patterns of cfDNA, researchers are unlocking new possibilities for early disease detection, including cancer and prenatal testing. This cutting-edge field combines insights from epigenetics and nucleosome positioning to develop sensitive diagnostic tools that could transform healthcare.
- Blog post
5hmC is far more than just a transient step in the DNA demethylation pathway as it has broad implications for gene regulation, cellular differentiation, brain function, genome stability, and disease.
- Blog post
Understanding the factors that affect DNA methylation can open up new avenues to explore human health and disease.
- Blog post
Explore the fascinating world of the different types of epigenetic modifications and the role of epigenetics in gene expression. Learn more.
- Blog post
Heterochromatin is a condensed form of chromatin that plays an essential role in maintaining genomic stability. Disruptions in its formation can lead to disease. We explore the mysteries of heterochromatin and its vital role in genome organisation.
- Blog post
Understanding how alterations in CpG island methylation contribute to disease states, including cancer, may provide novel targets for treatment.
- Scientific presentation
Watch this presentation, given by Chennan Li, PhD, from the National Cancer Institute, at the American Association of Cancer Researchers annual meeting 2025.
- Case study
The Munich Leukaemia Laboratory (MLL) are investigating the role of the 6-base genome to develop workfows that enable the detection of epigenetic patterns in leukemia patients.
- Poster
Patterns of 5hmC and 5hmC provide a view on tissue-specific gene expression.
- Poster
The combination of PARPi (Talazoparib – TAL) and DNMTi (Decitabine – DAC) functions synergistically to inhibit PCa cell lines and patient-derived PTOs.