Resources
Resource types
- Blog post
Liquid biopsy represents a groundbreaking advancement in disease diagnostics, offering a less invasive alternative to traditional tissue biopsies, particularly for cancer.
- News article
Our study investigates the roles of 5‑methylcytosine (5mC) and 5‑hydroxymethylcytosine (5hmC) as biomarkers for early-stage colorectal cancer (CRC) detection in cell-free DNA (cfDNA).
- Blog post
The utilisation of genetic biomarkers in liquid biopsy has caused a revolution in cancer diagnostics and personalised medicine.
- Poster
Here we show that the combination of resolved methylation and genomic data combined with machine-learning can generate accurate inference of gene expression (both steady-state and nascent), chromatin accessibility, and enhancer state, demonstrating the key role of 5mC and 5hmC in gene regulation.
- Poster
This study shows that 5mC and 5hmC taken together are highly effective as biomarkers for early-stage CRC detection in cfDNA.
- Poster
Here we present duet evoC: an enzymatic method that reads the four canonical bases in DNA together with complete epigenetic information encoded in DNA - as applied to single cells.
- Blog post
histone modifications play a crucial role in regulating gene expression and chromatin structure. These modifications work together in complex patterns to fine-tune cellular processes.
- News article
“Our goal is to provide researchers and liquid biopsy clinical test developers with innovative tools that enable them to reveal previously undetectable biological changes,”
- Blog post
By analysing the unique fragmentation patterns of cfDNA, researchers are unlocking new possibilities for early disease detection, including cancer and prenatal testing. This cutting-edge field combines insights from epigenetics and nucleosome positioning to develop sensitive diagnostic tools that could transform healthcare.
- Blog post
Discover the fascinating world of epigenetics, where our genes are influenced not only by our DNA but also by our environment.
- Blog post
Explore how liquid biopsy works for neurodegenerative disease diagnosis; including advantages over traditional methods and promising biomarkers.
- Blog post
5hmC is far more than just a transient step in the DNA demethylation pathway as it has broad implications for gene regulation, cellular differentiation, brain function, genome stability, and disease.
