Resources
Resource types
- News article
Alfonso Bellacosa, MD, PhD, a Professor in the Nuclear Dynamics and Cancer Research Program and Johnathan R. Whetstine, PhD, the Jack Schultz Chair in Basic Science, both at Fox Chase.
- Blog post
Most transposable elements (TE) lay dormant, buried under repressive epigenetic marks that ensure their influence over cell behaviour remains minimal. When they awaken, however, the consequences can be far reaching.
- Poster
Professor Ellen Heitzer’s lab at the Medical University of Graz analysed eight samples from localised PCa, metastatic PCa, and suspicious Pca (men with elevated serum PSA and/or suspect digital rectal examination but negative biopsy) using the duet multiomics solution evoC.
- News article
Exciting news, Professor Anjana Rao’s lab at La Jolla Institute for Immunology has published a new study with Nature Structural & Molecular Biology. Learn how 6-base sequencing can reveal early biomarkers of genome dysfunction.
- News article
In this preprint, Assistant Professor Emily Hodges' lab at Vanderbilt University used differentiating neural stem cells as a model system to understand the relationship between DNA methylation and genome dynamics.
- News article
In this preprint, learn how Associate Professor Alex Bick's lab at Vanderbilt University Medical Center conducted a multiracial meta-analysis of epigenome-wide association studies (EWAS) of Clonal Hematopoiesis of Indeterminate Potential (CHIP).
- News article
As well as helping researchers identify tumour DNA amid the soup of regular cell-free DNA, the fact that different tissues have distinct methylation patterns can help explain where the cell-free DNA might be coming from. “There are many advantages to being able to study epigenomics in concert with genomic features,” says Dawson.
- Webinar
Burleen Chhatwal from University College London, UK, will demonstrate how biomodal’s 6-base genome supported the successful analysis of both 5mC and 5hmC modifications in Parkinson’s disease compared to controls in a pilot study.
- Poster
Learn how 6-base sequencing reveals 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC) have important roles in the regulation of genome dynamics. Deregulation of TET can spur an increase of 5hmC in heterochromatin which could potentially be an early biomarker of genome dysfunction that lead to diseases.
- Poster
To address the difficulties of analysing methylation data, this poster presents modality, an efficient and scalable analysis package for 5- and 6-base genomes.
- Poster
This poster demonstrates that the combination of 5mC and 5hmC is highly effective for early-stage CRC detection in cfDNA - read it now.
