OGT prevents DNA demethylation and suppresses the expression of transposable elements in heterochromatin by restraining TET activity genome-wide

OGT prevents DNA demethylation and suppresses the expression of transposable elements in heterochromatin by restraining TET activity genome-wide

Research paper shows 6-base sequencing can reveal early biomarkers of genome dysfunction that lead to diseases

Exciting news, Professor Anjana Rao’s Lab at La Jolla Institute for Immunology has published a new study with Nature Structural & Molecular Biology. Read more to learn how 6-base sequencing reveals:

  • 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC) have important roles in the regulation of genome dynamics 
  • Deregulation of TET can spur an increase of 5hmC in heterochromatin which could potentially be an early biomarker of genome dysfunction that leads to diseases

This is a groundbreaking insight into the power of the 6-base genome delivered by duet evoC!

Read the full research paper

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