Download this poster Credits Fabio Puddu¹ Annelie Johansson¹ Aurélie Modat¹ Jamie Scotcher¹ Riccha Sethi¹ Nick Harding¹ Mark Hill¹ Ermira Lleshi¹ Casper Lumby¹ Jean Teyssandier¹ Michael
Download this poster Credits Robert Crawford¹ Hugo Sepulveda Xiang Li Leo J. Arteaga-Vazquez Isaac F. López-Moyado Melina Brunelli Lot Hernandez Espinosa Xiaojing Yue J. Carlos
To address the difficulties of analysing methylation data, this poster presents modality, an efficient and scalable analysis package for 5- and 6-base genomes.
This poster demonstrates that the combination of 5mC and 5hmC is highly effective for early-stage CRC detection in cfDNA – read it now.
Understanding the factors that affect DNA methylation can open up new avenues to explore human health and disease.
Deoxyribonucleic acid, or DNA, is the fundamental building block of life. Let’s explore the fascinating types of DNA in the world.
Liquid biopsy represents a groundbreaking advancement in disease diagnostics, offering a less invasive alternative to traditional tissue biopsies, particularly for cancer.
Our study investigates the roles of 5‑methylcytosine (5mC) and 5‑hydroxymethylcytosine (5hmC) as biomarkers for early-stage colorectal cancer (CRC) detection in cell-free DNA (cfDNA).
The utilisation of genetic biomarkers in liquid biopsy has caused a revolution in cancer diagnostics and personalised medicine.
Here we show that the combination of resolved methylation and genomic data combined with machine-learning can generate accurate inference of gene expression (both steady-state and nascent), chromatin accessibility, and enhancer state, demonstrating the key role of 5mC and 5hmC in gene regulation.
